As one’s muscle contracts during exercise, it
induces cytokine interleukin-6 (IL-6) gene expression
locally in contracting skeletal muscles. Likewise, an
exercising limb releases high amounts of IL-6 into the
blood. In fact, IL-6 levels increase dramatically
(≤100-fold) in response to exercise .
The IL-6 that is produced passes through the
bloodstream and eventually binds to its receptor on
IL-6 binding induces the LDLR gene by acting on its
promoter site; thus, further enhancing the binding of
nuclear proteins to their cognate DNA sequence of the LDLR
promoter (not shown). In turn, stimulating LDLR
Consequently, the LDLR activity on the surface of
liver cells is enhanced, leading to an increased uptake of
LDL from the circulation .